Efficacy and safety of lowering dietary intake of total fat, saturated fat, and cholesterol in children with elevated LDL cholesterol: the Dietary Intervention Study in Children

Journal Name: 
Am J Clin Nutr
Authors: 
Lauer,R.M.
Obarzanek,E.
Hunsberger,S.A.
Van Horn,L.
Hartmuller,V.W.
Barton,B.A.
Stevens,V.J.
Kwiterovich,P.O.,Jr.
Franklin,F.A.,Jr.
Kimm,S.Y.
Lasser,N.L.
Simons-Morton,D.G.
Abstract: 
BACKGROUND: Few studies have shown the efficacy and safety of lower-fat diets in children. OBJECTIVE: Our objective was to assess the efficacy and safety of lowering dietary intake of total fat, saturated fat, and cholesterol to decrease LDL-cholesterol concentrations in children. DESIGN: A 6-center, randomized controlled clinical trial was carried out in 663 children aged 8-10 y with LDL-cholesterol concentrations greater than the 80th and less than the 98th percentiles for age and sex. The children were randomly assigned to either an intervention group or a usual care group. Behavioral intervention promoted adherence to a diet providing 28% of energy from total fat,
11
2000
Volume: 
72
Pages: 
1332S-1342S
Keywords: 
150, adherence, administration & dosage, adverse effects, Aged, blood, Child, Child Nutrition, Cholesterol, Cholesterol,Dietary, clinical, clinical trial, Diet, diet therapy, Diet,Fat-Restricted, Dietary Fats, Dietary Fats,Unsaturated, differences, Female, Growth, hospital, Human, Hypercholesterolemia, intervention, Intervention Studies, Iowa, Lipoproteins,HDL Cholesterol, Lipoproteins,LDL Cholesterol, Male, Multicenter Studies, Pediatrics, PPRG, prevention & control, Research Design, Safety, Triglycerides, United States, Universities