Hypocarbia and adverse outcome in neonatal hypoxic-ischemic encephalopathy

Journal Name: 
J Pediatr
Authors: 
Pappas,A.
Shankaran,S.
Laptook,A.R.
Langer,J.C.
Bara,R.
Ehrenkranz,R.A.
Goldberg,R.N.
Das,A.
Higgins,R.D.
Tyson,J.E.
Walsh,M.C.
Abstract: 
OBJECTIVE: To evaluate the association between early hypocarbia and 18- to 22-month outcome among neonates with hypoxic-ischemic encephalopathy. STUDY DESIGN: Data from the National Institute of Child Health and Human Development Neonatal Research Network randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy were used for this secondary observational study. Infants (n = 204) had multiple blood gases recorded from birth to 12 hours of study intervention (hypothermia versus intensive care alone). The relationship between hypocarbia and outcome (death/disability at 18 to 22 months) was evaluated by unadjusted and adjusted analyses examining minimum PCO(2) and cumulative exposure to PCO(2)
5
2011
Volume: 
158
Pages: 
752-758
Keywords: 
analysis, blood, Carbon Dioxide, Child, Comparative Study, complications, Confidence Intervals, Development, electronic, epidemiology, etiology, Female, Health, Human, Humans, Hypocapnia, Hypothermia,Induced, Hypoxia-Ischemia,Brain, Infant, Infant,Newborn, intervention, Male, Medicine, Methods, Mortality, Odds Ratio, Pediatrics, regression, Regression Analysis, Research, Research Support, support, Survival Rate, therapy, Treatment Outcome, United States, Universities