Increased prevalence of abnormal glucose tolerance among obese siblings of children with type 2 diabetes

Journal Name: 
J Pediatr.
Levitt Katz,L.E.
OBJECTIVE: To test the hypothesis that overweight siblings of children with type 2 diabetes mellitus (T2DM) have a higher prevalence of abnormal glucose tolerance (AGT) compared with other overweight children. STUDY DESIGN: This was a cross-sectional study of overweight (body mass index [BMI] >or= 95(th) percentile) subjects, age 8 to 17 years, with at least 1 sibling age >or= 12 years. The primary outcome was AGT, as assessed by the oral glucose tolerance test (2-hour glucose >or= 140 mg/dL). The secondary outcome was insulin resistance by homeostasis model assessment (HOMA). RESULTS: The sibling (n=20) and control (n=42) groups were similar in terms of age, sex, racial distribution (largely African American), pubertal status, and BMI. The prevalence of AGT in the sibling group was 40.0% (n=8), compared with 14.3% (n=6) in controls (P= .048, Fisher exact test; unadjusted odds ratio=4.0; 95% confidence interval=1.2 to 13.5). Univariate analysis did not identify confounders for either outcome. There were no significant differences in HOMA or hemoglobin A1c between the 2 groups. CONCLUSIONS: Overweight siblings of children with T2DM had 4 times greater odds of having AGT compared with other overweight children. This group may represent a particularly high-risk population to target for screening and pediatric T2DM prevention
140, Adolescent, African American, African-American, analysis, Body Mass Index, Child, Comorbidity, Cross-Sectional Studies, Diabetes, Diabetes Mellitus, Diabetes Mellitus,Type 2, differences, electronic, epidemiology, Family Health, Female, Glucose Tolerance Test, Homeostasis, hospital, Humans, Insulin, Insulin Resistance, Logistic Models, Male, Mass Screening, Metabolic Syndrome X, Obesity, Overweight, Philadelphia, population, Prevalence, prevention & control, Research, Research Support, Siblings, support, Time