Optimizing early child development for young children with non-anemic iron deficiency in the primary care practice setting (OptEC): study protocol for a randomized controlled trial

Journal Name: 
Trials
Authors: 
Abdullah,K.
Thorpe,K.E.
Mamak,E.
Maguire,J.L.
Birken,C.S.
Fehlings,D.
Hanley,A.J.
Macarthur,C.
Zlotkin,S.H.
Parkin,P.C.
Abstract: 
BACKGROUND: Three decades of research suggests that prevention of iron deficiency anemia (IDA) in the primary care setting may be an unrealized and unique opportunity to prevent poor developmental outcomes in children. A longitudinal study of infants with IDA showed that the developmental disadvantage persists long term despite iron therapy. Early stages of iron deficiency, termed non-anemic iron deficiency (NAID), provide an opportunity for early detection and treatment before progression to IDA. There is little research regarding NAID, which may be associated with delayed development in young children. The aim of this study is to compare the effectiveness of four months of oral iron treatment plus dietary advice, with placebo plus dietary advice, in improving developmental outcomes in children with NAID and to conduct an internal pilot study. METHODS/DESIGN: From a screening cohort, those identified with NAID (hemoglobin >/=110 g/L and serum ferritin
2015
Volume: 
16
Pages: 
132-
Keywords: 
150, 40, analysis, Anemia, Behavior, Canada, Child, Child Development, deficiency, Development, electronic, evaluation, Faculty, Ferritin, Health, Health Policy, hospital, Infant, Iron, knowledge, Laboratories, laboratory, Learning, Longitudinal Studies, medical, Medicine, Nutrition, Nutritional Sciences, Pediatrics, Physicians, primary care, protocol, psychology, Public Health, regression, rehabilitation, Research, Research Support, Sample Size, support, therapy, Universities